The Korean Journal of Pharmacology (대한약리학회지)

The Korean Society of Pharmacology (대한약리학회)
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Influences of Diazepam and Naloxine on the increase of Plasma Corticosterone Level induced by Morphine and Pentazocine

Morphine과 Pentazocine의 혈장 Corticosterone 증가작용에 미치는 Naloxone 및 Diazepam의 영향

  • Chun, Boe-Gwun (Department of Pharmacology, College of Medicine, Korea University) ;
  • Park, Jung-Yul (Department of Pharmacology, College of Medicine, Korea University) ;
  • Cho, Geun-Haeng (Department of Pharmacology, College of Medicine, Korea University) ;
  • Kim, Soo-Kyung (Department of Pharmacology, College of Medicine, Korea University)
  • 전보권 (고려대학교 의과대학 약리학교실) ;
  • 박정율 (고려대학교 의과대학 약리학교실) ;
  • 조근행 (고려대학교 의과대학 약리학교실) ;
  • 김수경 (고려대학교 의과대학 약리학교실)
  • Published : 1983.06.30
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Abstract

The influences of diazepam and naloxone on the increase of plasma corticosterone level induced by morphine, pentazocine, ACTH, or picrotoxin were investigated in male mice. The results obtained were summarized as follows: 1) The increase induced by morphine or pentazocine of plasma corticosterone level was not affected by naloxone pretreatment but markedly suppressed by diazepam pretreatment. 2) The increase induced by ACTH of plasma corticosterone level was not affected by diazepam or naloxone pretreatment. 3) The picrotoxin markedly increased plasma corticosterone level, and the inceease was not affected by diazepam or naloxone pretreatment. This above results suggest that the increase induced by opioids of plasma corticosterone level seems to be rather related with other than opiate- or GABArerecptor.

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