Pharmacological Studies on the Antihypertensive Effects of Cinnarizine Coadministered with Propranolol or Metoprolol(I) -Effects on Blood Pressure Change-

Cinnarizine을 Propranolol이나 Metoprolol과 병용할 때의 혈압(血壓) 강하(降下) 효과(效果)에 관한 약리학적(藥理學的) 연구(硏究)(I) -혈압(血壓) 변화(變化)에 대한 효과-

The effects of $Ca^{2+}-antagonist$, cinnarizine, on the antihypertensive effects of propranolol and metoprolol were investigated in normal cat (i. v.) and SHR (p. o.). Cinnarizine increased the antihypertensive effect of propranolol, but not of metoprolol. It inhibited the heart rate decreasing effects of propranolol and metoprolol slightly. It decreased the norepinephrine-induced blood pressure increasing effect and isoproterenol-induced blood pressure decreasing effect when coadministered with metoprolol orally for 4 weeks in SHRs.