Bioavailability of Sustained Release Capsules of Ascorbic Acid in Guina Pigs

Guinea Pig에 있어 Asorbic Acid 지속성(持續性) 캅셀 제제(製劑)의 생체이용율(生體利用率)에 관(關)한 연구(硏究)

Bioavailability studies in guinea pigs and dissolution tests of sustained release capsules of ascorbic acid were investigated comparing with those of solution. The results were as follows; 1. In the dissolution test sustained release capsules released 90% of ascorbic acid after 12 hours, and ascorbic acid in the chewable tablet was dissolved. completely within 10 minutes. 2. In the determination of total ascorbic acid concentration in serum, the area under the curve between 0 and 24 hours $(AUC\;0{\sim}24h)$ ana the maximum serum concentration $(C_{max})$ did not show any significant difference between solution and sustained release capsule. The time to the maximum concentration $(C_{max})$ and the time over $50{\mu}g/ml$ concentration showed significant difference. 3. The time reached to maximum excretion rate $(T_{max})$ in sustained release capsule was longer than that of solution.