The Korean Journal of Physiology
- 제20권1호
- /
- Pages.103-124
- /
- 1986
- /
- 0300-4015(pISSN)
무마취 가토 신장기능에 미치는 Atrial Natriuretic Factor의 영향
Effect of Atrial Natriuretic Factor on the Renal Function and Renin Release in Unanesthetized Rabbit
- Lee, June-K. (Department of Physiology, Jeonbug National University Medical School) ;
- Cho, Kyung-W. (Department of Physiology, Jeonbug National University Medical School)
- 발행 : 1986.06.30
초록
Since it has been suggested that atrial receptor may be involved in the mechanism of extracellular volume regulation, it was shown that the granularity of atrial cardiocytes can be changed by water and salt depletion, and that an extract of cardiac atrial tissue, when injected intravenously into anesthetized rats, was shown to cause a large and rapid increase in renal excretion of sodium. Various natriuretic peptides were isolated and synthetized, and the effects were investigated by many workers. Most studies, however, have been carried out under anesthesia and there have teen some controversies over direct effect of the factor on the renal function. Therefore, it was attempted in this study to access the effects of an atrial extract and a synthetic natriuretic factor in unanesthetized rabbits. Intrarenal arterial infusion of atrial extract caused a rapid increase of urinary volume and excretion of sodium. Glomerular filtration rate and renal plasma flow were both increased with no change in filtration fraction. The ventricular extract produced no change in urinary excretion of electrolytes, nor in renal hemodynamics. Intrarenal infusion of synthetic atrial natriuretic factor caused increases of renal excretory rate of sodium, chloride and potassium, and
키워드