Studies on the Seasonal Variation of Berberine Contents in Berberis koreana

매자나무중 Berberine함량(含量)의 계절적(季節的) 변화(變化)에 관한 연구(硏究)

  • 유승조 (성균관대학교 약학대학) ;
  • 이경복 (아이오와대학교 약학대학) ;
  • 곽종환 (성균관대학교 약학대학)
  • Published : 1986.06.30

Abstract

The determination of berberine in Berberis koreana was examined by the high performance liquid chromatography using ${\mu}-Bondapak$ $C_{18}$ column and $CH_3CN/phosphate$ buffer (pH 5.2) (60/40) as a mobile phase. The seasonal variations of berberine contents in Berberis koreana were as follows; 1) In roots, the average berberine content was 0.94% with the highest level of 1.32% in October. 2) In stems, their average berberine content was about 0.1% and in March, April, October and November, the contents were relatively high. 3) In leaves, however, the content was as low as 0.005%. According to the experimental results obtained, we found that Berberis koreana roots can serve as the useful natural plant resources for the berberine and October is the optimal season for the collection.

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