Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Antagonism of Analgesic Effect of Morphine in Mice by Ginseng Saponins

인삼 사포닌의 몰핀 길항작용

  • Kim, Hack-Seang (College of Pharmacy, Chungbuk National University) ;
  • Oh, Ki-Wan (College of Pharmacy, Chungbuk National University) ;
  • Oh, Se-Kwan (College of Pharmacy, Chungbuk National University)
  • 김학성 (충북대학교 약학대학 약학과) ;
  • 오기완 (충북대학교 약학대학 약학과) ;
  • 오세관 (충북대학교 약학대학 약학과)
  • Published : 1986.12.20
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Abstract

Ginseng total saponins(GS), protopanaxadiol saponins(PD) and protopanaxadiol saponins(PT) antagonized the analgesia in mice induced by morphine. The administrations of 2,4-dihydroxyphenylalanine, and 5-hydroxytryptophan reduced the GS, PD and PT antagonisms of morphine analgesia. Possible mechanisms involved in the antagonistic actions of GS, PD and PT on morphine analgesia were described.

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