The Korean Journal of Physiology
- Volume 21 Issue 2
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- Pages.225-239
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- 1987
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- 0300-4015(pISSN)
Effect of Adenosine on the Mechanical and Electrical Activities of Guinea-pig Stomach
기니피그 위 평활근의 기계적 및 전기적 활동에 대한 아데노신 효과
- Kim, Heui-Jeen (Department of Pediatrics, College of Medicine, Seoul National University) ;
- Ko, Kwang-Wook (Department of Pediatrics, College of Medicine, Seoul National University) ;
- So, In-Suk (Department of Physiology, College of Medicine, In Ha University) ;
- Kim, Ki-Whan (Department of Physiology, College of Medicine, Seoul National University)
- Published : 1987.12.30
Abstract
The effects of adenosine on the mechanical contractions and electrical activities were investigated in guinea-pig stomach. Spontaneous contractions of the antral region were recorded with force transducer, and the phasic contractions of fundic region were induced by electrical field stimulation. Electrical responses of smocth muscle cells were recored using glass capillary microelectrodes filled with 3M-KCl. Field stimulation was applied transmurally by using a pair of platinum wire (0.5 mm in diameter) placed on both sides of tissue. All experiments were performed in tris-buffered Tyrode solution which was aerated with 100%