Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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The Effect of Schizandrae fructus Extract on Blood Constituents of Alloxan-Induced Diabetic Rabbits

오미자추출물(五味子抽出物)이 Alloxan 부하가귀(負荷家鬼)의 혈청성분(血淸成分)에 미치는 영향(影響)

  • Sheo, Hwa-Joong (Department of Food and Nutrition, College of Industry, Chosun University) ;
  • Lee, Myung-Yul (Department of Food and Nutrition, College of Industry, Chosun University) ;
  • Hwang, Gyoung Sook (Department of Food and Nutrition, College of Industry, Chosun University)
  • 서화중 (조선대학교 산업대학 식품영양학과) ;
  • 이명열 (조선대학교 산업대학 식품영양학과) ;
  • 황경숙 (조선대학교 산업대학 식품영양학과)
  • Published : 1987.11.30
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Abstract

The effect of Schizandrae fructus extract (S.F.E.) on experimentally alloxan-induced diabetes in rabbits and the acute toxicity on mice were studied; $LP_{50}$ of the extract was 21.50g/kg by intraperitoneal administration in mice. S.F.E. showed more rapid recovering effect than the control group : all samples showed excellent effect of lowering the hyperglycemia, that is, the blood glucose level was significantly decreased by 800mg/kg in 2 days and by 200mg/kg in 6 days. SGPT activity was lowered promptly after 4 days in 800mg/kg. Total cholesterol level was not shown significant lowering effect by 200mg/kg, but rapid by 800mg/kg in 6 days; blood urea nitrogen level was decreased gradually in 800mg/kg after 10 days and 14 days in 200mg/kg. In histological studies of pancreas, the sample groups exhibited less karyorrhexis, vacuolar and vesicular change, more stable in contents of ${\beta}-cells$ than the control group.

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