Effects of Panax Ginseng on the Development of Morphine Tolerance and Dependence -on antagonisms of morphine analgesia by ginsenosides-

인삼이 몰핀내성 및 의존성 형성에 미치는 영향 - 수종의 ginsenoside에 의한 몰핀진통력 길항작용에 관하여 -

Antagonisms of the analgesic effect of morphine in mice by ginsenoside Rbl, Rb2, Rgl and Re were investigated in these experiments. These ginsenosides antagonized the analgesic effect induced by morphine in mice and the administration of 2,4-dihy-droxyphenylalanine or 5-hydroxytryptophan reduced the antagonisms of morphine analgesia by the ginsenosides. Possible mechanisms involved in the antagonistic actions of the ginsenosides on morphine analgesia were described.