Archives of Pharmacal Research
- Volume 10 Issue 2
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- Pages.115-120
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- 1987
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Antithrombotic activities of saponins from Ilex pubescens
- Han, Yong-Nam (Natural Products Research Institute, Seoul National University) ;
- Baik, Soung-Kyung (College of Pharmacy, Sookmyung Womens University) ;
- Kim, Tae-Hee (College of Pharmacy, Sookmyung Womens University) ;
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Han, Byung-Hoon
(Natural Products Research Institute, Seoul National University)
- Published : 1987.06.01
Abstract
Methanol extract of Ilex pubescens roots prolonged bleeding time threefold, and inhibited the generation of malondialdehyde released during platelet aggregation inducted by thrombin. Through several purification procedures, its saponin, named ilexoside, was proved to be responsible for the antithrombotic activities of the plant. Ilexosides A, -D and -J and 24-carboxypomolic acid showed strong inhibitory activities on platelet aggregation induced by thrombin.
Keywords
- Ilex pubescers Aquifoliaceae;
- saponin triterpene;
- antithrombotic activity;
- ilexoside;
- ziyu-glycoside;
- 20-epipomolic acid;
- 24-carboxypomolic acid;
- pomolic acid;
- ilexolic acid;
- ginseoside