YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Serum Cholesterol Level Lowering Effect from the Underground Parts of Rosa rugosa

해당화 지하부의 혈청 Cholesterol치 저하효과

  • 양한석 (부산대학교 약학대학) ;
  • 박종철 (부산대학교 약학대학) ;
  • 최재수 (부산수산대학 식품영양학과) ;
  • 정해영 (일본 부산의과대학화한약연구소 임상이용부)
  • Published : 1987.12.01
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Abstract

The present paper describes the serum cholesterol level lowering effect of the underground parts of Rosa rugosa(Rosaceae) which have been used in a folkloric medicine for treating diabetics. The methanol extract was shown to lower the serum lipid level against the normal and 1% cholesterol and 0.5% cholic acid diet feeding to rats, respectively. When various fractions prepared from the above methanol extract was administered, the ethyl acetate-soluble fractions lowered the serum cholesterol level most remarkably. And when (+)-catechin from the ethyl acetate-soluble fractions was only administered to them, the serum cholesterol level was significantly lowered to 260$\pm$9.3mg/dl, the decrease of 17% for the control group. Therefore, it is suggested that (+)-catechin is one of the active principles of this plant.

Keywords

References

  1. 한국식물도감(상) 정태현
  2. 原色和潢藥圖鑑(下) 難波恒雄
  3. 新訂 和漢藥 赤松金芳
  4. 中藥大辭典 v.4 江蘇新醫學院
  5. 난치병과 한약 육창수;김정태
  6. 대한약학회 학술대회 요약집 해당화 근 액기스의 항염 및 진통작용에 관한 연구 허인희;맹영진
  7. 연세 의대 논문집 v.10 해당화 뿌리 추출액이 혈당치에 미치는 영향 송선옥;김광현;강두희
  8. Formacia v.19 Chemical composition of Rosa rugosa, Carotenoid centents Retezeanu,M.;Tarpo,E.;Drocan,R.
  9. Spensk. Kem. Tids. v.47 The coloring matter in the fruits of Rosa rugosa Willstaedt,H.
  10. Rolno-Spazyw;C.A. v.5;69 Changes in sugar content during ripening of Rosa rugosa fruits Lewicki,R.
  11. Chem. Communications;C.A v.8;30 Glucosides in the fruits of Rosa rugosa Vodocek,F.;Seari,C.
  12. Conn. Agri. Expt. Sta. Bull. v.447 Vitamin C content of the fruit of the Rosa Bailey,E.M.
  13. J. Japan. Soc. Food Nutrition v.1 The vitamins of rosa rugosa Inagaki,C.;Saito,S.
  14. Chem. Pharm. Bull. v.30 Rugosin A,B,C, and praecoxin A, Tannins having a valoneoyl group Okuda,T.;Hatano,T.;Yazaki,K.;Ogawa,N.
  15. Farmacia v.20 Chemical study of Rosa rugosa Ⅱ. Retezeanu,M.;Tarpo,E.;Drocan,R.
  16. Sigenkenho v.45 Flavonoids of various Rosa species (Ⅰ) Noguchi,M.
  17. Agric. Biol. Chem. v.43 Indentification of flavonoids in nineteen Rosaceae species Kaneta,M.;Hikitschi,H.;Endo,S.;Sugiyama,N.
  18. 생약학회지 v.17 海棠花 뿌리의 成分 硏究 金貞姬;朴榮順
  19. 중앙대학교 대학원 석사학위 청구논문 해당화 뿌리의 성분에 관한 연구 정태화
  20. Kor. J. Pharmacog. v.18 Isolation of (+)-catechin from the roots of Rosa regosa Young,H.S.;Park,J.C.;Choi,J.S.
  21. Cancer Chemother. Rep. v.29 Studies on the diabetogenic actions of STZ Rakieten,N.;Rakieten,M.L.;Nadrini,M.V.
  22. J. Nutr. Sci. Vitaminol. v.32 Effect of green tea catechins on plasma cholestetol level in cholestetol-fed rats Muramatsu,K.;Fukuyo,M.;Hara,Y.
  23. Ind. J. Exper. Biol. v.19 Cholestetol lowering action of vitamin P-like compounds in rats Basarkar,P.W.;Nath,N.
  24. 日藥理誌 v.81 四鑒化炭素에 의한 慢性 肝障害 흰쥐 및 肝部分 切除에 의한 再生 肝흰쥐에 對한 cianidanol (KB-53)의 作用 佐藤巖;武部 秀太郞;田島滋;池田 善明;伊藤敬三;能勢 尙志