Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Liquid Chromatographic Resolution of Racemic Drugs on Various $\alpha$-Arylalkylamine Derived Chiral Stationary Phases

  • Hyun, Myung-Ho (Department of Chemistry, College of Natural Science, Pusan National University) ;
  • Pirkle, William H. (Department of Cehmistry, University of Illinois)
  • Published : 1987.02.20
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Abstract

After conversion to their 3,5-dinitrobenzoyl or 3,5-dinitroanilide derivatives, the enantiomers of a number of drugs may be chromatographically separated on various ${\alpha}$-arylalkylamine-derived chiral stationary phases (CSPs). While each CSP used in this study is useful, CSP 1 is best able to resolve the 3,5-dinitroanilide derivative of Ibuprofen while CSP 9 generally gives rather large ${\alpha}$ values for the resolution of 3,5-dinitrobenzoyl derivatives of the enantiomers of ${\beta}$-adrenergic blocking drugs.

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References

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  1. The chiral chromatographic separation of β-adrenoceptor blocking drugs vol.10, pp.6, 1987, https://doi.org/10.1016/0731-7085(92)80057-t