Toxicological Research
- 제3권2호
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- Pages.89-96
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- 1987
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
ELIMINATION PATTERNS OF ARTERIAL BLOOD CYANIDE ION IN THIOSULFATE-OXYGEN ADMINISTERED RABBIT
-
Yoo, Keun-Young
(Department of Preventive Medicine and Forensic Medicine, Seoul National University)
;
-
Lee, Yoon-Seong
(College of Medicine Seoul National University)
;
- Yun, Dork-Ro (Department of Preventive Medicine and Forensic Medicine, Seoul National University)
- 발행 : 1987.12.01
초록
To test the efficacies of thiosulfate in cyanide poisoning with or without oxygen, after the administration of sublethal dose of potassium cyanide, serial arterial blood samples were collected during 60 minutes in 15 rabbits. Cyanide ion concentrations were measured by Conway cell microdiffusion method, and arterial oxygen tensions were also observed. Comparison of elimination constants showed that arterial blood cyanide ion concentration decreased most rapidly in the thiosulfate with oxygen-administered group. The elimination of cyanide ion by the action of thiosulfate in acutely poisoned rabbit accelerated probably due to oxygen and elimination pattern seems to occur by first-order elimination kinetics.