Toxicological Research
- Volume 4 Issue 1
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- Pages.1-12
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- 1988
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Effect of Smoking on Theophylline Pharmacokinetics in Normal Korean Volunteers
- Park, Kyoung-Ho (Department of Pharmacy, Seoul National University Hospital) ;
- Shin, Hyun-Teak (Department of Pharmacy, Seoul National University Hospital) ;
- Kim, Nak-Doo (College of Pharmacy, Seoul National University)
- Published : 1988.06.01
Abstract
In order to evaluate the effect of cigarette smoking on the pharmacokinetics of theophylline in Koreans, doses of 4.5 to 5.0 mg/kg of theophylline, as injectable aminophylline, were administered to 12 normal young volunteers (male, 22 to 35 yrs;mean, 26 yrs) through intravenous infusion over 30 minutes, and pharmacokinetics of theophylline were tested. Among subjects, six were nonsmokers and the other were smokers (range 1 to 2 packs/day). Also the correlations between plasma and saliva theophylline concentrations were investigated by determining the concentrations of theophylline in saliva simultaneously at each plasma sampling time. The total body clearances of theophylline in smokers (Mean
Keywords
- Pharmacokinetics;
- theophylline;
- saliva concentration;
- human volunteers;
- aminophylline;
- smoking cigarette;
- metabolism;
- clearance