YAKHAK HOEJI (약학회지)
- Volume 33 Issue 4
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- Pages.237-240
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- 1989
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis of Tiaprofenic Acid
Tiaprofenic Acid의 합성
- Choi, Hong-Dae (Department of Chemistry, Dong-Eui University)
- 최홍대 (동의대학교 화학과)
- Published : 1989.08.28
Abstract
A new synthetic method for tiaprofenic acid, which is a potent anti-inflammatory agent, was described. Friedel-Crafts reaction of thiophene with ethyl
Keywords
- Tiaprofenic acid;
- anti-inflammatory agent;
- Friedel-Crafts reaction;
- thiphene;
- ethyl ${\alpha}-chlocro-{\alpha}-(methylthio)$ acetate;
- ethyl ${\alpha}-methylthio-2-thiopheneacetate$;
- ethyl ${\alpha}-methyl-2-thiopheneacetate$;
- desulfurization;
- zinc dust-acetic acid;
- ethyl ${\alpha}-methyl-{\alpha}-methylthio-2-thiopheneacetate$;
- benzoylation;
- hydrolysis;
- ethyl $5-benzoyl-{\alpha}-methyl-2-thiopheneacetate$