Reactions of Purine Derivatives with Phosphorus Pentnoxide and Triethylamine and Their Antitumor Effects

  • Moharram, H.H. (National Organisation For Drug Control and Research, P.O.Box 29, Cairo and Cancer Institute, Cairo University) ;
  • Osman, A.M. (National Organisation For Drug Control and Research, P.O. Box 29, Cairo and Cancer Institute, Cairo University)
  • Published : 1989.03.01

Abstract

6-Arylamino-3,7-dihydro-3,7-dimethy-2-oxo-1H-purine and 2-arylimino-6-arylamino-3,7-dihydro-3,7-dimethyl-1H-purine were obtained in a one-pot reaction when 3,7-dihydro-3,7-dimethyl-1H-purine-3,6-dione, phosphorus pentaoxide, triethylamine hydrochloride and appropriate amine amino are heated at $170^{\circ}$. Some derivatives were tested for their antitumor activity.

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