The Study of Copper Metabolism by Protein Intake and Status of Copper Intake in Young Adult Womon

한국 성인 여자의 구리 섭취 상태 및 단백질에 의한 구리 대사에 관한 연구

The study was designed to examine the of effects of level of protein intake on Cu metabolism in 6 healthy young adult women. The subjects were given 4 levels of protein diet, 0.45g (period I), 0.60g (period III), 0.75g (period II) and 0.90g (period IV) of protein per Kg of body weight and 0.86mg 0.70mg, 1.86mg and 2.34mg of Cu per day for 5 days respectively. During the experimental period, urine sample were collected everyday and fecal sample were collected for last 2 days of each dietary period. The samples were analyzed for Cu contents. Mean daily urinary Cu excretion were $0.12{\pm}0.03mg$ for period I, $0.16{\pm}0.02mg$ for period III, $0.35{\pm}0.08mg$ for period II and $0.11{\pm}0.02mg$ for period IV, and the mean daily urinary excretion of Cu was not affected significant difference by the level of protein intake. Mean daily fecal Cu excretion were $0.12{\pm}0.03mg$ for period I, $0.16{\pm}0.02mg$ for period III, $0.35{\pm}0.08mg$ for period II and $0.11{\pm}0.02mg$ for period IV, and the mean daily urinary excretion of Cu was not affected significant difference by the level of protein intake. Mean dailey Mean dailey fecal Cu excretion were $1.23{\pm}0.16mg$ for period I, $1.28{\pm}0.25mg$ for period III, $0.99{\pm}0.01mg$ for period II and $1.85{\pm}0.19mg$ for period IV, and the difference of the 2 periods I vs IV was significant(p<0.05). Mean dailey cu balance were $0.48{\pm}0.14mg$ for period I, $0.74{\pm}0.26mg$ for period III, $0.52{\pm}0.12mg$ for period II and $0.38{\pm}0.20mg$ for period IV, and the difference of the 2 periods I vs IV was significant(p<0.05).

건강한 여대생을 대상으로 하여 1일 총 열량은 체중 1kg당 40kcal, 단백질은 체증 1kg당 0.45g (I 단계식이), 0.60g(III 단계식이), 0.75g(II 단계식이), 0.90g(IV 단계식이)의 4가지 수준으로 조정한 식이를 각각 5일간씩 20일간 섭취시키고 구리의 섭취량, 배설량 및 대사를 관찰한 결과는 다음과 같다. 1. I, III, II 와 IV단계 식이내의 구리함유량은 각각 0.86mg, 0.70mg, 1.86mg,과 2.34mg이었다. 2. 소변중의 평균구리배설량은 I, III, II과 IV단계 식이섭취 기간 동안 각각 $0.12{\pm}0.03mg$, $0.16{\pm}0.02mg$, $0.35{\pm}0.08mg$과 $0.11{\pm}0.02mg$ 단백질 섭취량에 따른 유의적인 변화는 없었다. 3. 대변중의 평균 구리배설량은 I, III, II과 IV단계 식이섭취 기간 동안 각각 $1.23{\pm}0.16mg$, $1.28{\pm}0.25mg$, $0.99{\pm}0.01mg$과 $1.85{\pm}0.19mg$으로 4단계별 단백질 섭취량에 따른 유의적인 차이는 없었으나 I 단계와 IV 단계 식이섭취 기간 동안 대변중 평균 구리배설량에는 유의적인 차이가 있었다.(p<0.05). 4. 평균 구리 balance는 I, III, II과 IV단계식이섭취 기간 동안 각각 $-0.48{\pm}0.14mg$, $-0.74{\pm}0.26mg$ $0.52{\pm}0.12mg$과 $0.38{\pm}0.20mg$으로 4단계별 단백질 섭취량에 따른 유의적인 변화는 있었으나 I 단계와 IV 단계 식이 섭취시의 평균 구리 balance에는 유의적인 차이가 있었으며(p(0.05), 대변중의 구리배설량과 음의 상관관계를 나타냈다.(p<0.05).