Journal of Ginseng Research
- Volume 13 Issue 1
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- Pages.8-13
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- 1989
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
Effects of Ginseng Leaf Saponins on the Development of Morphine Tolerance and Dependence in Mice
인삼잎 사포닌이 몰핀의 내성 및 의존성 형성에 미치는 영향
- Kim, Hack-Seang (College of Pharmacy, Chunghuk National University) ;
- Kim, Sun-Hye (College of Pharmacy, Chunghuk National University) ;
- Lee, Myung-Koo (College of Pharmacy, Chunghuk National University) ;
- Choi, Kang-Ju (Korea Ginseng and Tobacco Research Institute) ;
- Kim, Suk-Chang (Korea Ginseng and Tobacco Research Institute)
- Published : 1989.06.01
Abstract
The effects of orally administered ginseng leaf saponins(GLS) on the analgesic action of morphine, the development of morphine induced tolerance and physical dependence, and the hepatic flutathione contents in mice were investigated. GLS antagonized the analgesic action of morphine and inhibited the development of morphine induced tolerance and physical dependence. It also inhibited the decrease in hepatic glutathione level induced by multiple injections of morphine.