Archives of Pharmacal Research
- Volume 12 Issue 3
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- Pages.207-213
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- 1989
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Studies on the mechanism of cytotoxicities of polyacetylenes against L1210 cell
- Kim, Young-Sook (Korea Ginseng and Tobacco Research Institute) ;
- Jim, Seung-Ha (Korea Ginseng and Tobacco Research Institute) ;
- Kim, Shin-Il (Korea Ginseng and Tobacco Research Institute) ;
- Hahn, Dug-Ryong (College of Pharmacy, Chung Ang University)
- Published : 1989.09.01
Abstract
This study was performed to investigate the mechanism of in vitro cytotosic actions of polyacetylenes which are panaxydol, panaxynol and panaxytriol isolated from Panax ginseng C. A. Meyer. DNA synthesis of L1210 cells was significantly inhibited with dose dependent pattern when L1210 cells were treated for 1 hour with over 5 .mu.g/ml of polyacetylenes. Panaxydol which had the most potent cytotoxicity among three polyacetylenes showed also the strongest inhibitory effect on DNA synthesis. Intracellular cyclic AMP levels of L1210 cells treated with 2.5
Keywords
- polyacetylene;
- panaxydol;
- panaxynol pnanxytriol;
- cytotoxicity;
- Panax ginseng C.A. Meyer;
- L1210 cell;
- DNA synthesis;
- cyclic AMP;
- glycolysis;
- membrane damdage