Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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The changes of plasma prostaglandin E2 level and natural killer cell activity in EL-4 leukemia cells bearing mice

EL-4 암세포주(癌細胞株) 이식(移植)마우스에서의 혈중(血中) prostaglandin E2 농도(濃度) 및 자연살해세포(自然殺害細胞) 활성도(活性度)의 변화(變化)

  • Kim, Sung-ho (Laboratory of Cancer Pathology, Korea Cancer Center Hospital)
  • 김성호 (원자력병원 암병리학연구실)
  • Received : 1989.08.18
  • Published : 1989.10.28
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Abstract

The changes of plasma prostaglandin $E_2$ level, natural killer cell activity and tumor cell growth were assayed after transplantation of EL-4 leukemia cells in C57BL/6 mice. The results were summarized as follows; 1. Plasma prostaglandin $E_2$ level was increased in EL-4 bearing mice, but indomethacin treated mice group showed low level. 2. The tumor-derived prostaglandin $E_2$ inhibited the post-target binding cytolytic process of natural killer activity. 3. Indomethacin inhibited the growth of prostaglandin secreting EL-4 solid tumor.

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