Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Studies on the Hypoglycemic Effect of ginseng Polypeptide

인삼의 폴리펩티드 성분의 혈당저하에 미치는 영향

  • Wang, B.X. (Department of Pharmacology, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province) ;
  • Yang, M. (Department of Pharmacology, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province) ;
  • Jin, Y.L. (Department of Pharmacology, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province) ;
  • Cui, X.Y. (Department of Pharmacology, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province) ;
  • Wang, Y. (Department of Pharmacology, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province)
  • Published : 1990.08.01
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Abstract

The ginseng Polypeptide (GPP) Isolated from the root of Panax ginseng C.A. Meyer was domonstrated to decrease the levels of blood sugar and hepatic glycogen when injected intravenoilsly to rats at a doses of 50-200 mg/kg without affecting blood total lipid. When mice were injected slibclitaneollsly daily at a dose of 50 and 100 mg/kg for 7 successive days. GPP was also found to decrease blood sligar and hepatic glycogen. In addition, GPP was found to decrease variolls experimental hypergly cemias induced by injection of adrenaline, glilcose and alloxan. GPP exhibited inhibiting effect on the glut rogen enhancement indllced by glucose, but strenthening effect on the glycogen decrease indliced by adrenaline. When the levels of blood total lipid and lilrer glycogen were increased by T alloxan. GPP was shown to inhibit these changes except its lowering blood sugar. The toxicity of GPP is very low, LD50 was found to be 1.62 $\pm$ 0.130 g/kg for iv.

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