Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
권호 표지

Biological Activities of Non-saponin Compounds Isolated from Korean Red Ginseng

고려홍삼에서 분리된 비사포닌 화합물의 생물활성

  • Hiromichi Okuda (2nd Department of Medical Biochemistry, School of Medicine Ehime University) ;
  • Lee, Sung-Dong (2nd Department of Medical Biochemistry, School of Medicine Ehime University) ;
  • Yukinaga Matsuura (2nd Department of Medical Biochemistry, School of Medicine Ehime University) ;
  • Yinan Zheng (2nd Department of Medical Biochemistry, School of Medicine Ehime University) ;
  • Keizo Sekiya (2nd Department of Medical Biochemistry, School of Medicine Ehime University) ;
  • Takeshi Takaku (Central Research Laboratory, School of Medicine, Ehime University) ;
  • Kenji Kameda (Central Research Laboratory, School of Medicine, Ehime University) ;
  • Kumi Hirose (Institute of PHarmaceutical Sciences School of Medicine Hiroshima University) ;
  • Kazuhiro Ohtani (Institute of PHarmaceutical Sciences School of Medicine Hiroshima University) ;
  • Osamu Tanaka (Institute of PHarmaceutical Sciences School of Medicine Hiroshima University) ;
  • Toshiie Sakata (1st Department of Internal Medicine School of Medicine Kyushu University)
  • Published : 1990.08.01
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Abstract

We have been isolating various physiologically active substances from non-saponin fraction of Korean Red Ginseng. These are adenosine, pyre-glutamic acid, dencichine and acidic polysaccharide. Adenosine and pyre-glutamic acid are known to inhibit epinephrine-induced lipolysis in fat cells and stimulate the insulin-mediated lipogenesis. In addition to these actions, adenosine was found to inhibit both norepinephrine- and histamine-induced aorta constriction, and pyre·glutamic acid inhibits angiotensin-converting enzyme. Dencichine stimulated histamine-induced aorta constriction. Finally, acidic polysaccharide was found to inhibit both lipolytic and anorexigenic actions of Toxohormone-L. Based on these experimental results, I presented a briefreview on these compounds isolated from non-saponin fraction of Korea Red Ginseng.

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