Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Cycloadditiona reaction of 5-(2-thienyl)methylene derivatives of thiazolidinone-4-thiones and their antimicrobial activities

  • Ead, Hamed A. (Department of Chemistry Faculty of Science ,University of Cairo) ;
  • Metwalli, Nadia H. (Department of Chemistry Faculty of Science ,University of Cairo) ;
  • Morsi, Nagwa M. (Department of Botany, Faculty of Science, University of Cairo)
  • Published : 1990.03.01
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Abstract

The cycloaddition of the newely synthesized 5-(2-thienyl)methylene derivatives of thiazolidinone-4-thiones, 2a-c to acrylonitrile (3a), ethylacrylate (3b), N-phenylmaleimide (6) and dimethyl fumarate (8) has been evaluated. Under thermal reaction conditions [4 +2] cycloaddition proceeds with complete site and regioselectivity to yield the cycloadduct, 4, 5, 7 and 9, respectively. The antimicrobial activities of some of the new products were tested.

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