Archives of Pharmacal Research
- Volume 13 Issue 2
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- Pages.180-186
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- 1990
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Bioequivalence Study of Ranitidine Tablet
- Shim, Chang-Koo (College of Pharmact, Seoul National University) ;
- Hong, Jae-Sung (College of Pharmact, Seoul National University) ;
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Lee, Chang-Ki
(National Institute of Safety Research) ;
- Han, Ik-Soo (National Institute of Safety Research) ;
- Choi, Kwang-Sik (National Institute of Safety Research)
- Published : 1990.06.01
Abstract
A bioequivalence study of ranitidine tablets was conducted according to the Korean Guidine for the Bioequivalence Test using twelve healthy male subjects. The plasma concentration-timecurves of ranitidine from the test and reference tablets showed profound multiple peak phenomenon in each subject as reported earlier. However, the area under the plasma concentration-time curve (AUC) and the maximum ploasma concentration at the first peak (