Bulletin of the Korean Chemical Society

  • 제11권5호
  • /
  • Pages.376-379
  • /
  • 1990
  • /
  • 0253-2964(pISSN)
  • /
  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Structure and Activity of Quinolone Antibacterial Agents. 1. 7-Substituted 1-Ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids

  • Shin, Youn-Ho (Korea Research Institute of Chemical Technology) ;
  • Ryu, Eung K. (Korea Research Institute of Chemical Technology) ;
  • Kang, Young-Kee (Department of Chemistry, Chungbuk National University)
  • 발행 : 1990.10.20
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초록

To find out a correlation between antibacterial activity and physical properties of 7-substituted 1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, dipole moments, charge distributions, and hydrophobicities were calculated. The atomic charges and the dipole moments to not give any correlations with inhibition of DNA gyrase, but the calculated hydration free energies show some correlations.

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