Korean Journal of Veterinary Research (대한수의학회지)
- Volume 30 Issue 3
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- Pages.283-286
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- 1990
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
Effect of nifedipine against carrageenan-induced paw oedema in rats
흰쥐에서 carrageenan에 의한 족부종(足浮腫)에 대한 nifedipine의 영향
- Shin, Dong-ho (College of Veterinary Medicine, Chonnam National University)
- 신동호 (전남대학교 수의과대학)
- Received : 1990.05.13
- Published : 1990.07.31
Abstract
The effects of nifedipne and verapamil were compared on carrageenan-induced paw edema in rats and the results are summarized as follows: Carrageenan induced severe acute paw edema within 30 minutes and the maximum effect was achieved around 4 hours after administration. The carrageenan-induced paw edema was prominantly reduced by pretreatments of indomethacin (2mg/kg, p.o.) and nifedipine (10 and 20mg/kg, i.p.), whereas verapamil had no effect on the carrageenan-induced paw edema. These results suggest that calcium antagonists, nifedipine and verapamil, have a different effect on the inflammatory response induced by carrageenan.