Archives of Pharmacal Research
- Volume 14 Issue 4
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- Pages.379-384
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- 1991
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
The Knoevenagel Reaction of Malononitrile with Acetylacetone: New Route of Pyrazole, Pyrazolo[2,3-C]pyridine, Benzene, Pyridazine and Benzo[C]pyridazine Derivatives
- Mohareb, Rafat Milad (Chemistry Department, Faculty of Science, Cairo University)
- Published : 1991.12.01
Abstract
The Knoevenagal reaction of malononitrile and acetylacetone gave the acyclic product 3 which was separated in a good yield and identified. The reactivity of 3 towards some chemical reagents is studied. Thus, the reaction of 3 with aromatic aldehydes, hydrazines and cyanomethylene derivatives gave products 6-12. Reaction of 3 with benzenediazonium chloride gave the primidine derivative 14.