Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

The Effect of Ginsenosides on Galactosamine-induced Hepatotoxicity

인삼 사포닌이 간세포 독성에 미치는 영향

  • 김선여 (서울대학교 약학대학) ;
  • 김영중 (서울대학교 약학대학) ;
  • 변순정 (서울대학교 약학대학) ;
  • 김은 (한국인삼연초연구소)
  • Published : 1991.12.30
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Abstract

Liver protective effects of ginsenosides as well as fractions of dammarane glycosides of Panax ginseng were studied using galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes. Preventing effects on GalN-induced hepatotoxicity were found both microscopic observation and determination of GPT level with total dammarane glycosides fraction and $20(S)-ginsenoside-Rb_1$ as well as $20(S)-ginsenoside-Rg_1$ at the concentration of $50{\mu}g/ml$. The syntheses of both protein and RNA were significantly increased by the treatment of $50{\mu}g/ml$ of total dammarane glycoside fraction, $20(S)-ginsenoside-Rb_1$, -Rc, -Re and $-Rg_1$, respectively in both normal and GalN-induced cytotoxic hepatocytes.

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