Pharmacological Studies on the Sopunghwalhul-Tang -On Analgesic, Antiinflammation and Hypotension-

소풍활혈탕(疎風活血湯)의 약효에 관한 연구(硏究) -진통(鎭痛), 항염증(抗炎症) 및 혈압(血壓)에 미치는 효과에 대하여-

This study was attempted to examine the acute toxicity and the effect of Sopunghwalhul-Tang water extract(SHTE) on analgesic action in mice, anti- inflammatory action in rats and blood pressure in rabbits. The results were as follows; SHTE showed 10% mortality at 2,000mg/kg(p.o.), had significant analgesic activity in the pain caused by 0.7% acetic acid and was shown to have significant anti-inflammatory activity in the edema-induced by 5% acetic acid at 450mg/kg. SHTE given into a ear vein of rabbits produced a dose-related vasodepressur responses. SHTE-induced hypotension was significantly inhibited by pretreatment with atropine, but was not affected by chlorisondamine, phentolamine, propranolol, and dephenhydramine.