약학회지 (YAKHAK HOEJI)

  • 제36권2호
  • /
  • Pages.137-139
  • /
  • 1992
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

2-(4-비페닐일)부티르산의 합성

Facile Synthesis of 2-(4-Biphenylyl)butyric Acid

  • Choi, Hong-Dae (Department of Chemistry, Dongeui University) ;
  • Yun, Ho-Sang (Department of Chemistry, Dongeui University) ;
  • Kang, Byung-Won (Department of Chemistry, Dongeui University) ;
  • Son, Byeng-Wha (Department of Chemistry, National Fisheries University of Pusan) ;
  • Jung, Woo-Jin (Department of Chemistry, National Fisheries University of Pusan)
  • 발행 : 1992.04.29
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초록

A new method for xenbucin, which is a antihypercholesteremic agent, is described. Friedel-Crafts reaction of biphenyl with ethyl ${\alpha}-chloro-{\alpha}-(methylthio)acetate(1)$ afforded ethyl 2-methylthio-2-(4-biphenylyl)acetate(2). Ethyl 2-(4-biphenylyl)butyrate(4) was obtained by ethylation of (2) with NaH and $C_2H_5I$, followed by desulfurization of the resultant ethyl 2-methylthio-2-(4-biphenylyl)butyrate(3) with zinc dust in acetic acid. Xenbucin was synthesized by hydrolysis of (4).

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