흰쥐에서 할로페리돌에 의해서 유발된 강경증에 미치는 후구 적출의 영향

Effects of Olfactory Bulbectomy on Catalepsy Induced by Haloperidol in Rats

We attempted to clarify the effect of bilateral olfactory bulbectomy on catalepsy induced by haloperidol in rats. The incidence of catalepsy induced by haloperidol remarkably increased after lesion of olfactory bulb, which was significantly inhibited by L-5-hydroxytryptophan, L-DOPA, and ginseng's total saponin but reserpine and ${\alpha}-methyl-p-tyrosine$ were ineffective. The dopamine content of brain was significantly decreased by olfactory bulbectomy, but this result was reversed by ginseng's total saponin.