Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Controlled Drug Delivery through O-Diethylaminoethyl Chitosan Membrane

O-디에칠아미노에칠 키토산막을 통한 약물방출조절

  • Kim, Jin-Hong (Dept. of Industrial Chemistry, College of Engineering, Hang-Yang University) ;
  • Lee, Young-Moo (Dept. of Industrial Chemistry, College of Engineering, Hang-Yang University)
  • 김진홍 (한양대학교 공과대학 공업화학과) ;
  • 이영무 (한양대학교 공과대학 공업화학과)
  • Published : 1992.03.20
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Abstract

A novel O-diethylaminoethyl chitosan (DEAE-chitosan) was synthesized via Schiff's reaction between chitosan and benzaldehyde. $C_2$ amino group was protected via Schiffs base reaction with benzaldehyde to form N-benzylidene chitosan. After reaction with diethylaminoethyl chloride, Schiffs base was removed by reacting O-diethylaminothyl-N-benzylidene chitosan and hydrochloric acid. Tensile strength of DEAE-chitosan was improved due to the incorporation of bulky side group in $C_6$ position of chitosan. DEAE-chitosan showed a pH-dependent swelling characteristics. Release rate of riboflavin was dependent on the water content of DEAE-chitosan that is a function of crosslinking degrees.

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