Preparation and Characterization of Poly$({\gamma}-benzyl\;L-glutamate)$/Poly(ethylene oxide)-Lactoselactone Block Copolymers and Their Microspheres

Poly$({\gamma}-benzyl\;L-glutamate)$/Poly(ethylene oxide)-Lactoselactone 블록공중합체와 이들의 미립자 제조 및 특성

A series of biodegradable block copolymers consisting of $poly({\gamma}-benzyl\;L-glutamate)$ (PBLG) and poly(ethylene oxide) (PEO)-lactoselactone were prepared by polymerization of PEO-lactoselactone and ${\gamma}-benzyl$ L-glutamate-N-carboxyanhydride and characterized by IR and NMR. From circular dichroism measurements, it was found that the polymers exist in the ${\alpha}-helical$ conformation. Block copolymer microspheres were prepared by solvent-extraction-precipitation method for their primary evaluation for medical and biological applications.