Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Release of Cytarabine from $Poly({\varepsilon}-carbobenzoxy\;L-lysine)$/Poly(ethylene oxide)/Poly({\varepsilon}-carbobenzoxy\;L-lysine)$ Block Copolymer Microspheres

$Poly({\varepsilon}-carbobenzoxy\;L-lysine)$/Poly(ethylene oxide)/$Poly({\varepsilon}-carbobenzoxy\;L-lysine)$ 블록 공중합체 미립자에서 Cytarabine의 방출특성

  • Cho, Chong-Su (Department of Polymer Engineering, Chonnam National University) ;
  • Kwon, Joong-Kuen (Department of Chemical Engineering, Junior College of Chosun University) ;
  • Jo, Byung-Wook (Department of Chemical Engineering, Chosun University) ;
  • Lee, Kang-Choon (Department of Pharmacy, Sungkyunkwan University) ;
  • Sung, Yong-Kiel (Department of Chemistry, Dongguk University)
  • 조종수 (전남대학교 고분자공학과) ;
  • 권중근 (조선대학교 공업전문대학 화공과) ;
  • 조병욱 (조선대학교 화학공학과) ;
  • 이강춘 (성균관대학교 약학과) ;
  • 성용길 (동국대학교 화학과)
  • Published : 1992.12.20
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Abstract

$Poly({\varepsilon}-carbobenzoxy\;L-lysine)/poly(ethylene oxide)/poly({\varepsilon}-carbobenzoxy\;L-lysine)$ (LEL) block copolymers containing $poly({\varepsilon}-carbobenzoxy\;L-lysine)$ (PCLL) as the A component and poly(ethylene oxide) (PEO) as the B component were investigated as drug delivery matrix. PCLL homopolymer and LEL block copolymer microspheres containing anticancer drug, cytarabine, were prepared by a solvent evaporation process and the release patterns of cytarabine from the microspheres were investigated in vitro. The size of PCLL homopolymer and LEL block copolymer microspheres was ranged from $0.2\;{\mu}m$ to $1\;{\mu}m$ in diameter and the shape of the microspheres was almost round. The release pattern of cytarabine from the block copolymer microspheres was dependent on the mole % of PEO of the block copolymers.

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