Behaviorpharmacological Studies of Standardized Ginseng Extract G115 on the Central Dopaminergic Activity(I)

표준화된 인삼추출물 G115의 중추도파민신경계에 대한 행동약리학적 연구(I)

  • 김용호 (충남대학교 약학대학) ;
  • 김선장 (충남대학교 약학대학, 충북대학교 약학대학)
  • Published : 1992.04.01

Abstract

Central dopaminergic activity of standardized ginseng extract G115 was investigated in comparison with those induced by haloperidol in rats. The effects of G115 on the locomotor activity and, stereotyped behavior induced by apomorphine, which interacts directly with dopamine receptor were observed. Apomorphine(2 mg/kg) significantly decreased locomotor activity, whereas it showed a markdly increased incidence of stereotyped behavior. Standardized ginseng extract G115(100 mg/kg) and haloperidol(1 mg/kg) showed a significant decrease in locomotor activity but not induced stereotyped hehavior. Locomotor activity induced by apomorphine was markdly decreased by haloperidol(1 mg/kg), but that was significantly increased by standardized ginseng extract G115(50 mg/kg). Stereotyped behavior induced by apomorphine was completely supressed haloperidol(1 mg/kg), but was not changed by standardized ginseng extract G115. These results suggest that standardized ginseng extract G115 plays an important role in central dopaminergic activity, and haloperidol and standardized ginseng extract G115 seem to have a different action in behavior.

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