Archives of Pharmacal Research
- Volume 15 Issue 1
- /
- Pages.20-29
- /
- 1992
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Effects of Squalene on the Immune Responses in Mice(II):Cellular and Non-specific Immune Response and Antitumor Activity of Squalene
- Ahn, Young-Keun (College of Pharmcay, Won Kwang University) ;
- Kim, Joung-Hoon (College of Pharmcay, Won Kwang University)
- Published : 1992.03.01
Abstract
Effects of squalene on cellular and non-specific immune responses and antitumor activity in mice were investigated. Cellular and non-specific immunological assay parameters adopted in the present study were delayed-type hypersensitivity reaction and resette forming cells (RFC) for cellular immunity, activities of natural killer (NK) cells and phagocyte for non-specific immunity. Squalene resulted in marked increases of cellular and non-specific immune functions and enhancement of host resistance to tumor challenge in dose-dependent manner.
Keywords
- Squalene;
- delayed-type hypersensitivity reaciton;
- rosette forming cell;
- natrual killer cell activity;
- phagocytic activity;
- host resistance to tumor challenge