Archives of Pharmacal Research
- Volume 15 Issue 1
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- Pages.69-72
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- 1992
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
The Oxidative Iodination of Pyrimidine Bases and their Nucleosides using Iodine/Dimethylformamide/m-Chloroperbenzoic Acid
- Hwang, Chang-Ho (College of Pharmacy, Chungbuk National University) ;
- Park, Jung-Sup (College of Pharmacy, Chungbuk National University) ;
- Won, Jeong-Hee (College of Pharmacy, Chungbuk National University) ;
- Kim, Jae-Nyoung (Korea Research Institute of Chemical Technology) ;
- Ryu, Eung K. (Korea Research Institute of Chemical Technology)
- Published : 1992.03.01
Abstract
Pyrimidine bases and their mucleosides were oxidatively iodinated at C-5 position by the reaction of iodine in DMF (dimethylformamide) with MCPBA (m-chloroperbenzoic acid) under mild conditions. For uracil derivatives such as uracil 1a. 1, 3-dimethyluracil 1b, uridine 1c, and 2'-deoxyuridine 1d, the corresponding 5-iodo derivatives were obtained in high yields (71-95%). The iodination of cytidine 3a and 2'-deoxycytidine 3b was achieved in moderate yields (41-56%).