Archives of Pharmacal Research
- Volume 15 Issue 4
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- Pages.333-335
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- 1992
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Practical Hofmann Rearrangement
- Jew, Sang-Sup (College of Pharmacy, Seoul National University) ;
- Park, Hyeung-Geun (College of Pharmacy, Seoul National University) ;
- Kang, Myoung-hee (College of Pharmacy, Seoul National University) ;
- Lee, Tae-hee (College of Pharmacy, Seoul National University) ;
- Cho, Youn-sang (College of Pharmacy, Seoul National University)
- Published : 1992.12.01
Abstract
Hofmann rearrangement of a series of primary aliphatic and aromatic carboxamides 1a-1m with HgO-NBS (or dibromantin)R'OH-DMF gives corresponding carbamates 2a-2m in excellent yields.