Archives of Pharmacal Research
- Volume 15 Issue 4
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- Pages.343-346
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- 1992
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
A Synthetic Study on Cyclic Phosphate Derivatives of Seconucleosides as Potential Antiviral Agents (II):Synthesis of 3',5'-Cyclic Phosphates of 6-aza-2'-azido-secouridine
- Shin, Dae-Hong (College of Pharmacy, Seoul National University) ;
- Yang, Jae-Wook (College of Pharmacy, Seoul National University) ;
- Kim, Joong-Hyup (Korea Institute of Science and Tchnology) ;
-
Lee, Chong-Kyo
(Korea Research Institute of Chemical Technology)
;
- Chung, Won-Keun (College of Pharmacy, Seoul National University) ;
- Chun, Moon-Woo (College of Pharmacy, Seoul National University)
- Published : 1992.12.01
Abstract
The synthesis of 6-aza-3', 5'-p-nitrophenylphosphoryltrioxy-2'-azido-2'-deoxy-2', 3' secouridine and 6-aza-3', 5'-phosphoryltrioxy-2'-azido-2'-deoxy-2', 3'-secouridine ammonium salt are described and they were evaluated for antiviral activity primarily against DNA and RNA viruses and found to be inactive, but no significant cytocidal effect was observed against Vero and Hela cell.