Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
권호 표지

Effect of Deoxynivalenol on Immunoglobulin in the Mouse

Mouse에서의 Deoxynivalenol이 면역글로브린에 미치는 영향

  • 이국천 (경상남도 가축위생시험소 북부지소) ;
  • 이주홍 (경상남도 가축위생시험소 북부지소) ;
  • 손성기 (경상남도 가축위생시험소 북부지소) ;
  • 주영국 (경상남도종축장)
  • Published : 1992.11.01
Download PDF
⟨ Previous Next ⟩

Abstract

Mice were fed semi-purified diets containing 0, 2, 10 and 25 ppm(mg/kg) deoxynivalenol over 8 weeks and were assessed for effects on bodyweight gain, serum immunolglobulin levels and surface immunoglobulin bearing lymphocyte ratio. 1. The rate of body-weight gain was significantly reduced (p＜0.05) at the 10 and 25 ppm of DON, whereas the mice ingesting the diet containing 2 ppm DON was not. 2. IgA in serum immunolglobulin was significantly increased (P＜0.05) at the 10 and 25 ppm of DON, but IgG, IgM were decreased, whereas exposure to 2 ppm DON was not change. 3. Concentration of IgA from Peyer's patch of mice fed DON exhibited increased at 10, 25 ppm. 4. Lymphocytes surface marker studies revealed that IgA, IgG and IgM were 2.2%, 0.4% and 1.5％ respectively. These results suggest that dietary exposure to DON alters regulation of IgA production

Keywords