Relaxation of P2-purinoceptor on isolated renal artery of rabbit

토끼 적출 신동맥에 있어서 P2-purinoceptor의 이완작용

  • Kim, Joo-heon (College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Yong-keun (College of Medicine, Busan National University)
  • Received : 1991.09.11
  • Published : 1992.01.30

Abstract

To elucidate the action of $P_2$-purinoceptor, effects of adenosine triphosphate(ATP) and perivascular nerve stimulation were investigated from polygraph in the isolated renal artery of rabbit 1. ATP caused the relaxation on the precontraction with noradrenaline$(10{\mu}M)$ on the presene and absence of endothelium in the isolated renal artery of rabbit, the relaxative response was increased between 0.1 and $30{\mu}M$ on dose-dependent manner. 2. The relaxative response induced by ATP$(10{\mu}M)$ on precontraction with noradrenaline$(10{\mu}M)$ was blocked by the pretreatment with reactive blue 2$(10{\mu}M)$. 3. ATP inhibited the contractile response by perivascular nerve stimulation(0.3ms, 80V, 50Hz, 1 sec), the inhibitory action was blocked by the pretreatment with 8-phenyltheophylline$(10{\mu}M)$.

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Acknowledgement

Supported by : 교육부