Acknowledgement
Supported by : 학술진흥재단
Arylsulfonyl urea derivatives can be easily prepared in good yield by treating amines with arylsulfonyl carbamates in aqueous solution : 1) N-Arylsulfonyl-N'-aryl urea derivatives, 2) N-Arylsulfony-N'-alkyl urea derivatives, 3) N-Arylsulfonyl-N'- heterocyclic urea derivatives. The proposed reaction mechanisms for preparing arylsulfonyl ureas involve formation of an ion-pair conformation by initial acid-base reaction, then formation of a so-called tetrahedral intermediate by nucleophilic addition, followed by an acid-catalyzed elimination of an alkoxide ion and loss of a proton.
수용액에서 amlne류와 arylsulfonyl carbamate류를 반응시켜 다음과 같은 arylsulfonyl urea유도체들을 좋은 수율로 쉽게 합성할 수 있다 : 1) N-Arylsulfonyl-N'-arylurea 유도체, 2) N-Arylsulfonyl-N'-alkyl urea 유도체, 3) N-Arylsulfonyl-N'-heterocyclic urea 유도체. Arylsulfonyl urea의 합성에 관한 반응메카니즘은, 먼저 산-염기 반응에 의해 ion-pair형태가 만들어지고, 그 다음 사면체형 중간체를 형성하는 친핵성첨가반응, 그리고 산촉매에 의한 alkoxide ion과 양성자의 제거반응에 따라 일어난다.
Supported by : 학술진흥재단