Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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The Effect of Cholesterol on the Property of Vesicle

Vesicle의 성질에 대한 콜레스테롤의 효과

  • Cho, Iw-Han (Department of Advanced Materials Engineering, Korea Advanced Institute of Science and Technology) ;
  • Moon, Kwon-Gi (Department of Chemistry, Chungbuk National University) ;
  • Shin, Jae-Sup (Department of Chemistry, Chungbuk National University)
  • 조의환 (한국과학기술원 서울분원 신소재공학과) ;
  • 문권기 (충북대학교 자연과학대학 화학과) ;
  • 신재섭 (충북대학교 자연과학대학 화학과)
  • Published : 1993.03.20
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Abstract

Polymerized vesicles were prepared from monomeric cholesterol-containing surfactant. These vesicles were used to extract the free cholesterol. To introduce spacer group into [cholesteryloxycarbonylmethyl] [2-(methacryloyloxy)ethyl]dimethylammonium chloride (CHODAMA), [5-[ (cholesteryloxy)carbonyl]pentyl] [2-(methacryloyloxy)ethyl]dimethylammonium bromide (CHODAMA-5) and [10-[(cholesteryloxy)carbonyl]decyl] [2-(methacryloyloxy)ethyl]dimethylammonium bromide (CHODAMA-10) were synthesized, In both case of polymerized vesicle with CHODAMA-5 and CHODAMA-10, the permeability was decreased and the amount of extracted cholesterol was also decreased, compared with the polymerized vesicle of CHODAMA.

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