Archives of Pharmacal Research
- Volume 16 Issue 1
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- Pages.25-28
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- 1993
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Antiinflammatory Activity of Naturally Occurring Flavone and Flavonol Glycosides
- Lee, Song-Jin (College of Pharmacy, Kangweon National University) ;
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Son, Kun-Ho
(Dept. Food and Nutrition, Andong National University) ;
- Chang, Hyeun-Wook (College of Pharmacy, Yeongnam University) ;
- Do, Jae-Chul (College of Pharmacy, Yeongnam University) ;
- Jung, Keun-Young (College of Pharmacy, Yeongnam University) ;
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Kang, Sam-Sik
(Natural Products Research Institute, Seoul National University) ;
- Kim, Hyun-Pyo (College of Pharmacy, Kangweon National University)
- Published : 1993.03.01
Abstract
Our previous report demonstrated that certain flavonoid aglycones such as apigenin (flavone), quercetin, morin (flavonols), and biochanin A (isoflavone) showed in vivo antiinflammatory activity via topical and oral routes of adminstation. As a continual study, the various flavonoid glycosides have been evaluated in mouse ear edema assay using archidonic acid or croton-oil as a inflammagen. Flavonoids were orally administered (2 mg/mouse) and ear edema inhibition was measured. Significant antiinflammatory activities were found esepcially in flavone and flavonol glycosides (15-29% inhibition) although the flavonoid derivatives tested showed less antiinflammatory activity than hydrocortisone or indomethacin. Chalcone and flavanone derivatives were not significantly active. And in general, flavonol glycosides of kaempferol-type were found to have a higher oral antiinflammatory activity than that of flavonol glycosides of quercetin-type in mice.