Toxicological Research

  • 제9권1호
  • /
  • Pages.107-118
  • /
  • 1993
  • /
  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

PERI-AND POSTNATAL STUDY OF RECOMBINANT HUMAN INTERFERON alphaA (LBD-007) IN RATS

  • Chung, Moon-Koo (Toxicology Center Korea Research Institute of Chemical) ;
  • Kim, Sung-Hoon (Toxicology Center Korea Research Institute of Chemical) ;
  • Roh, Jung-Koo (Toxicology Center Korea Research Institute of Chemical)
  • 발행 : 1993.06.01
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초록

LBD-007, a newly developed recombinant human interferon alphaA, was at dose levels of 0.3 $\times$$10^6$ , 6 $\times$ $10^6$ and 12 $\times$ $10^6$ IU/kg/day administered subcutaneously to pregnant and subsequent delivered SpragueDawley rats from day 17 of gestation through day 21 of lactation. Effects of test substance on dams and growth, behaviour and mating performance of F1 offspring were examined. 1. No treatmene-related changes in clinical signs, food consumption, body weight, pregnant period and necropsy findings were observed in dams.

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참고문헌

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