Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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EFFECT OF DITHIOL MALONATE DERIVATIVES (DMDs) ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN PRIMARY CULTURES OF ADULT RAT HEPATOCYTES

  • Jung, Hyun-Ho (Department of Life Science, Kwangju Institute of Science and Technology) ;
  • Jeong, Tae-Cheon (Department of Life Science, Kwangju Institute of Science and Technology) ;
  • Yang, Kyu-Hwan (Department of Life Science, Kwangju Institute of Science and Technology) ;
  • Chun, Young-Jin (Department of Life Science, Kwangju Institute of Science and Technology)
  • Published : 1993.12.01
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Abstract

Protective effects of dithiol malonate derivatives (DMDs), YH-100, YH-150 and YH-439 on carbon tetrachloride-induced hepatotoxicity were investigated in primary rat hepatocytes culture. Treatment of DMDs to hepatocytes culture did not affect total cytochrome P-450 content and ECOD and AHH activities. Protein and RNA synthesis was also similar to control. Meanwhile, DMDs significantly decreased LDH release and in vitro lipid peroxidation induced by $CCI_4$. Accumulation of cellular triglyceride and decreased secretion of VLDL from liver cells by $CCI_4$ treatment were also significantly protected.

Keywords

References

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