Induction of Metallothionein and Toxicity in Acute Cadmium Intoxicated Rat

카드뮴 급성폭로에 의한 Metallothionein 생성과 독성작용

  • Min, Kyung-Joon (Department of Preventive Medicine and Community Health, College of Medicine, Chung-Ang University) ;
  • Park, Jung-Duck (Department of Preventive Medicine and Community Health, College of Medicine, Chung-Ang University) ;
  • Hong, Yeon-Pyo (Department of Preventive Medicine and Community Health, College of Medicine, Chung-Ang University) ;
  • Chang, Im-Won (Department of Preventive Medicine and Community Health, College of Medicine, Chung-Ang University)
  • 민경준 (중앙대학교 의과대학 예방의학교실) ;
  • 박정덕 (중앙대학교 의과대학 예방의학교실) ;
  • 홍연표 (중앙대학교 의과대학 예방의학교실) ;
  • 장임원 (중앙대학교 의과대학 예방의학교실)
  • Published : 1993.06.01

Abstract

Thirty five male Sprague-Dawley rats were treated with cadmium chloride solution ranging from 0.2 to 3.2mg $CdCl_2/kg$ by intravenous single injection. At 48 hours after administration of cadmium, total cadmium, MT bound cadmium and histopathologic finding in liver, kidney, lung, heart, testis, metallothionein in liver, kidney and total cadmium in bleed were examined. Tissue cadmium concentration was highest in liver, followed by in kidney, heart, lung and testis. Cadmium bound to rnetallothionein (MT-Cd) and ratio of MT-Cd to total cadmium were increased in liver and kidney dependently of cadmium exposure dose, but not significantly changed in other organs. On histopathologic finding, the most susceptible organ was heart in considering cadmium exposed dose, but testis in considering cadmium concentration. Blood cadmium concentration was increased with dose-dependent pattern, and significantly correlated with tissue cadmium concentration, so that we may estimate tissue cadmium concentration by measurement of blood cadmium concentration. Metallothionein in liver and kidney was increased with dose-dependent pattern, higher in liver than in kidney, and was significantly correlated with tissue cadmium concentration. However, metallothionein induction efficiency of tissue cadmium(${\mu}g\;MT/{\mu}g\;Cd$) was eater in liver than in kidney, and reverse to tissue concentration or exposed dose of cadmium.

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