Comparison between Ursodeoxycholic Acid and Its ${\beta}-Cyclodextrin$ Inclusion Complex: in-vitro Dissolution, in-vivo Absorption and Choleretic Effect

우르소데옥시콜린산 및 이의 베타-시클로덱스트린 포접복합체간의 in-vitro 용출, in-vivo 흡수및 이담효과의 비교

Choleretic effect and absorption of ursodeoxycholic acid (UDCA) in rats were studied using UDCA alone and it's ${\beta}-cyclodextrin$ $({\beta}-CyD)$ inclusin complex (UDCA-IC). In spite of increase in solubility and dissolution rate, absorption of UDCA-IC was decreased compared with UDCA alone. Choleretic effect of UDCA-IC was also decreased. It looks that UDCA forms stronger inclusion complex with ${\beta}-CyD$ than any other drug or organic biological material. From this study, it was suggested that UDCA might be used as a new potential competing agent when inclusion complexes of drugs with ${\beta}-CyD$ were administered for the improvement of poor bioavailability.