YAKHAK HOEJI (약학회지)
- Volume 38 Issue 6
- /
- Pages.703-711
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- 1994
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Synthesis of D-1,3-Dioxolane and D-1,3-Oxathiolane Pyrimidine Nucleosides
D-1,3-Dioxolane 및 D-1,3-Oxathiolane 피리미딘 뉴크레오사이드의 합성
-
Hong, Joon-Hee
(College of Pharmacy, Seoul National University)
;
- Cha, Ma-Rie (College of Pharmacy, Seoul National University) ;
- Shin, Seong-Eun (College of Pharmacy, Seoul National University) ;
- Choi, Bo-Gil (College of Pharmacy, Chonnam National University) ;
- Chung, Byung-Ho (College of Pharmacy, Chonnam National University) ;
- Kim, Joong-Hyup (Korea Institute of Science and Technology) ;
-
Lee, Chong-Kyo
(Korea Research Institute of Chemical Technology)
;
- Chung, Won-Keun (College of Pharmacy, Seoul National University) ;
- Chun, Moon-Woo (College of Pharmacy, Seoul National University)
-
홍준희
(서울대학교 약학대학)
;
- 차마리 (서울대학교 약학대학) ;
- 신성은 (서울대학교 약학대학) ;
- 최보길 (전남대학교 약학대학) ;
- 정병호 (전남대학교 약학대학) ;
- 김중협 (한국과학기술연구원) ;
-
이종교
(한국화학연구소)
;
- 정원근 (서울대학교 약학대학) ;
- 천문우 (서울대학교 약학대학)
- Published : 1994.12.30
Abstract
We synthesized D-1,3-dioxolanyl acetate from D-mannose using Frazer-Reide reaction and D-1,3-oxathiolanyl acetate from either D-mannose or D-galactose in good yields. These acetates were conjugated with various disilylated pyrimidine base using trimethylsilyl trifluoromethane sulfonate as a Lewis acid catalyst to obtain 32 different D-nucleosides.
Keywords
- Anti-viral agent;
- D-1,3-oxathiolanyl acetate;
- D-1,3-dioxolanyl acetate;
- D-1,3-oxathiolanyl pyrimidine nucleoside;
- D-1,3-dioxolanyl pyrimidine nucleoside