Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Pharmacological Activities of Sesquiterpenes from the Rhizomes of Curcuma zedoaria

아출(莪朮)의 Sesquiterpene 성분의 약물활성

  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Yoon, Ki-Young (Natural Products Research Institute, Seoul National University) ;
  • Cho, Tae-Soon (College of Pharmacy, Sung Kyun Kwan University)
  • 신국현 (서울대학교 천연물과학연구소) ;
  • 윤기영 (서울대학교 천연물과학연구소) ;
  • 조태순 (성균관대학교 약학대학)
  • Published : 1994.09.30
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Abstract

Pharmacological activities of two sesquiterpenes, curzerenone(I), and curcumenol(II) isolated from the rhizomes of Curcuma zedoaria being used as an aromatic stomachic in Chinese medicines were evaluated in rats and mice. Curzerenone (I), at 100mg/kg, p.o. showed a potent protective effect against HCl-ethanol induced gastric lesion in rats, and curcumenol(II), at the same dose level showed a CNS depressant action characterized by a potentiation of hexobarbital(HB)-induced narcosis. Both compounds showed a moderate analgesic action but did not exhibit a hypothermic action even at 200mg/kg dose level.

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